Mandate
The 2005 Constitutional amendment under article 108A provided the Office of the Prime Minister with a Constitutional right of existence and mandated the Office to carry out the following functions:
1. Be Leader of Government business in Parliament
2. Be responsible for coordination and implementation of Government policies across Ministries, Departments and other public Institutions including policy and management issues on disaster and refugees, special programmes on pacification and development of Northern Uganda, Luwero Triangle, Karamoja region and Information and National guidance.

Mission
The Office of the Prime Minister is to instil and maintain efficient and effective systems in Government that enable Uganda to rapidly develop.

Goals
1.Establish mechanisms that will lead to synergies and linkages in the implementation of public policy.
2.Establish mechanisms that will promote coordinated and harmonized planning and budgeting at national and local Government levels that is responsive to Uganda’s needs.
3.Ensure efficient and effective use of public resource in the implementation of strategic priorities
4.To establish mechanisms that will lead to synergy and linkages in the Implementation of Public policy through harmonized planning and review processes
5.To facilitate legislative approval of Government policies, programmes and projects.

Functions
1. To ensure the efficient and effective use of Public Resources in the Implementation of Strategic Priorities
 2. To Lead Government Business in Parliament, monitor the proceedings of Parliament and liaise with Ministries on questions and issues raised by Parliament for a feed back
 3. Coordinate and Monitor Government policies, programmes and projects and facilitate the executive office decision making process by reporting the status of the performance of the policies and programmes to the President, Cabinet and Parliament
4. Chair Cabinet meetings in the absence of the President and Vice-President, in accordance with Article 112 of the Constitution;
5. Coordinate Government Policy and implementation of Special Programmes in Karamoja, Luwero Triangle, Northern Uganda;
6. Coordinate Government policy and management issues on refugees and disasters in the country;
7. Lead Public relations for government and coordinate issues on information and national guidance.

Vision
The Office of the Prime Minister, a sub-sector of the Public Sector Management, Security Conflict Resolution and Disaster Management, envisions “A Public Sector, which is Responsive and Accountable in steering Uganda towards Rapid Economic Growth and Development.” through working in harmony and collaboration with other Government line Ministries and Agencies.