The Office of the Prime Minister is also charged with development of capacities for prevention, preparedness and response to natural and human induced Disasters and Refugees in Uganda. Other functions include coordination and monitoring the implementation of special Government policies and programmes for Northern Uganda, Luwero Triangle/Rwenzori Region and Karamoja Region. OPM carries out this mandate under the following functions within Departments and Directorates.

The Executive Office in Office of the Prime Minister takes leadership of Government business in the Parliament of Uganda where the Rt. Hon Prime Minister is assisted by the Government Chief Whip in coordination and presentation of bills. The Executive responds to questions raised in Parliament on Government policies and programmes. The Rt. Hon Prime Minister also assists and represents H. E. the President of Uganda and the H. E. the Vice President to chair cabinet meetings on national and international functions . This is in addition to chairing Top Management and Inter-Ministerial meetings.

The Office of the Prime Minister is making operational  the Institutional Framework for Coordination of Policies and Programme  in the Government of Uganda  and implementing the Public Sector Management. In this respect the ministry coordinates evaluation of Uganda’s Development frameworks such as Poverty Eradication Action Plan (PEAP), conducts the Annual Policy Implementation Review (APIR), and Implements the Presidential Investors Round Table (PIRT) actions. In addition the Ministry plays part in developing the National Development Plan (NDP) with drafting of the monitoring and evaluation results and strategy of this plan.

Through formulation of policies on information and national guidance, the Ministry aims to ensure a well informed and mobilized society on the cohesive and sustainable national development. This is done through regulation of the media, providing for access to information by the public, coordinating the communication of Uganda Government policies and programmes and promoting the national values and common good.

The ministry coordinates development of capacities for prevention, preparedness, and response to natural and human induced disasters and refugees. The ministry carries out plans for food security, clearance of landmine and other explosive remnants of the war, coordinates and trains Inter-agency officers in Incident command systems in disaster management. Office of the Prime Minister assists and resettles internally displaced persons in the Uganda and receives and settles refugees from other countries.

The Office of the Prime Minister coordinates and monitors the implementation of special Government policies and programmes for Northern Uganda, Luwero/Rwenzori and Karamoja Regions. This comprises of designing, implementation and monitoring intervention programs and projects to cutter for special policy needs. In this way the ministry is supporting the recovery and development of Northern Uganda, Luwero /Rwenzori and Karamoja regions with special focus on areas of health, education, water, livelihood and peace building.

The Ministry has a finance and administration support department. This ensures proper use of and accounting for funds released for use by the Ministry. In addition it provides for adequate and proper manpower and logistical support in terms of the equipment and materials and to ensure their proper management of other departments. This is aimed at improving quality and efficiency of the output of the Office of the Prime Minister .