The Department is under the political leadership of the Minister for General Duties Hon.

The Directorate of Information and National Guidance, under the political leadership of the Minister for Information and National Guidance Hon.

Office of the Prime Minister(OPM) among others, is charged with coordination and implementation of policies that include Disaster, Preparedness, Management and Refugees.

The Office of the Prime Minister (OPM) is - among others - charged with the implementation of special programmes in Northern Uganda, Karamoja, Luwero and the Rwenzori region.