The Department is under the political leadership of the Hon. Minister for General Duties. Office of the Prime Minister is making operational the institutional framework for coordination of policies and Programme  in the Government of Uganda and implementing the Public Sector Management.

In this respect the ministry coordinates evaluation of Uganda's Development frameworks such as the National Development Plan (NDP), conducts the Government Annual (and semi-annual) Performance Report (GAPR), and Coordinates the Presidential Investors Round Table (PIRT) actions. .

The Directorate of Information and National Guidance, under the political leadership of the Minister for Information and National Guidance Hon. Mary B. Karooro Okurut contributes to fulfilling Office of the Prime Ministers major functions.
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Office of the Prime Minister(OPM) among others, is charged with coordination and implementation of policies that include Disaster, Preparedness, Management and Refugees. This department is under the political leadership of the Minister for Disaster Preparedness, Management and Refugees  Read more...

The Office of the Prime Minister (OPM) is - among others - charged with the implementation of special programmes in Northern Uganda, Karamoja, Luwero and the Rwenzori region..